Journal
BIOMATERIALS
Volume 34, Issue 18, Pages 4493-4500Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2013.02.050
Keywords
Cell penetration; Gene delivery; Nano-polyplex; Polyplex hydrogel; Small interference RNA (siRNA)
Funding
- Korea Institute of Science and Technology
- Ministry of Education, Science and Technology in Korea
Ask authors/readers for more resources
An approach for application of cell penetration to selective small interference RNA (siRNA) localized delivery system, cell penetrable nano-polyplex assembled hydrogel system, is presented. The cell penetrable nano-polyplex assembled hydrogelisprepared by protamine conjugation to poly(organophosphazene) and inducement of nano-polyplexes with siRNAs. After an injection of cell penetrable nano-polyplex solution into the body, it turns into a gel due to thermosensitivity of poly(organophosphazene). The gel maintains up to 4 weeks and the released 30 nm-sized nano-polyplexes from the gel induces highly effective siRNA delivery due to cell penetration. Accordingly, the new system shows a high gene silencing efficiency on only the target site in long-term with a single injection. (C) 2013 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available