Journal
PEPTIDES
Volume 21, Issue 4, Pages 559-564Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0196-9781(00)00185-6
Keywords
CGRP; osteoclast-like cell; disuse osteoporosis; neurological disorders
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Osteoclast-like cell (OCL-like) differentiation is increased in long term cultures of bone marrow taken from paralyzed areas of paraplegic patients. Among the neuropeptides recently described in bone, calcitonin gene-related peptide (CGRP) has been shown in animal studies to inhibit bone resorption in vivo and OCL-like differentiation in vitro: its deficiency could thus be a link between the neural lesion and increased OCL-like production in paraplegia and some other neurologic disorders. We therefore investigated in this study the effects of CGRP on human OCL-like formation and found that it indeed has an inhibitory effect mediated at least in part via cAMP. (C) 2000 Elsevier Science Inc. All rights reserved.
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