Journal
INFECTION AND IMMUNITY
Volume 68, Issue 4, Pages 1760-1764Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.68.4.1760-1764.2000
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Th1-type cellular immune responses play a critical role in protection against infection with Leishmania parasites, whereas activation of Th2-type cells results in progressive disease. Cutaneous leishmaniasis caused by Leishmania major is often a self-healing disease; however, persistent nonhealing forms are also known. In the present study we have described cell-mediated immune responses in nonhealing patients by measuring T-cell proliferation, cytokine production, and phenotypic characterization of these cells, The responses were compared with those of patients with active lesions, patients who had recovered from infection, and healthy controls. Peripheral blood mononuclear cells from patients with active lesions and recovered donors proliferated vigorously and produced Th1-type cytokine when stimulated with L. major antigens, whereas in nonhealing patients the proliferative responses were significantly lower and showed a Th2-type response to Leishmania antigens, Interleukin-10 (IL-10) production was not a feature oft. major stimulation, Flow cytometric analysis revealed that L. major antigen induced proliferation of the CD l-positive population and that these cells were the major source of gamma interferon and IL-4. These results show a distinct dichotomy in the cytokine response to L. major infection.
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