Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 181, Issue 4, Pages 1313-1321Publisher
UNIV CHICAGO PRESS
DOI: 10.1086/315405
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- NIAID NIH HHS [AI-35370] Funding Source: Medline
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The molecular mechanism of pneumococcal vaccine failure in human immunodeficiency virus (HIV)-infected persons is not fully understood. A polymerase chain reaction ELISA was used to determine the proportion of peripheral IgG, IgA, and IgM CD19-positive B cells expressing 6 immunoglobulin heavy-chain variable region (V-H) subgroups before and 7 days after pneumococcal vaccination of 12 HIV-infected and 12 HIV-uninfected subjects. Significant postvaccination increases in the expression of the V(H)3 subgroup by IgG and IgA and a greater serologic response to vaccination were observed in the HIV-uninfected group. In contrast, the HIV-infected group had reduced prevaccination IgG V(H)3 and a postvaccination increase in IgG V(H)5. These results demonstrate that pneumococcal vaccination changes the pattern of B cell V-H gene expression and support the concept that aberrant V(H)3 expression may translate into a poor antipneumococcal response in the setting of HIV infection.
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