Journal
JOURNAL OF NATURAL PRODUCTS
Volume 63, Issue 4, Pages 447-451Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np9903292
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Chemical investigation of the Et2O extract of the marine sponge Rhaphisia Lacazei resulted in the isolation of 13 pure bisindole alkaloids (1-13). Compounds (1-6) belong to the class of topsentins and have already been described. Compounds 7-13 are new products, closely related to the class of hamacanthins. The major compounds 1-3 were tested in vitro for antitumor activity; compounds 2 and 3 showed antiproliferative activity against human broncopulmonary cancer cells (NSCLC-NG) with an IC50 of 12 and 6.3 mu g/mL, respectively.
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