Journal
BIOMATERIALS
Volume 34, Issue 13, Pages 3467-3478Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2013.01.071
Keywords
Mesenchymal stem cells; Titania nanotubes; Zinc; Antibacterial property; Osteogenic differentiation
Funding
- National Natural Science Foundation of China [50902104, 31200716, 21105077]
- Hong Kong Research Grants Council (RGC) [CityU 112212]
- City University of Hong Kong [9667066]
- State Key Laboratory of High Performance Ceramics and Superfine Microstructure [SKL201109SIC]
- Fourth Military Medical University
- School of Stomatology, The Fourth Military Medical University
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Titanium implants having enhanced osteogenic activity and antibacterial property are highly desirable for the prevention of implant associated infection and promotion of osseointegration. In this study, coatings containing titania nanotubes (NTs) incorporated with zinc (NT-Zn) are produced on Ti implants by anodization and hydrothermal treatment in Zn containing solutions. The amount of incorporated Zn can be adjusted by varying the structural parameters such as the nanotube diameter and length as well as hydrothermal treatment time. The suitable NT-Zn coatings with good intrinsic antibacterial properties can prevent post-operation infection. Excellent osteogenesis inducing ability in the absence of extraneous osteogenic supplements is demonstrated and the ERK1/2 signaling is found to be involved. The NT-Zn structure which is simple, stable, and easy to produce and scale up has immense potential in bone implant applications. (C) 2013 Elsevier Ltd. All rights reserved.
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