Journal
INTERNATIONAL JOURNAL OF OBESITY
Volume 24, Issue 4, Pages 522-524Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.ijo.0801210
Keywords
PPAR-gamma; leptin; BMI; obesity
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Funding
- NCRR NIH HHS [MO1-RR-01346] Funding Source: Medline
- NHLBI NIH HHS [P01-HL45522] Funding Source: Medline
- NIAMS NIH HHS [R01-AR43351] Funding Source: Medline
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Peroxisome proliferator-activated receptors (PPAR) are transcription factors that regulate adipocyte differentiation and gene expression. We tested the hypothesis that the Pro12Ala variant of PPAR-gamma 2 is associated with obesity and type 2 diabetes-related traits in 921 subjects from the San Antonio Family Heart Study, Subjects with at least one Ala allele (n=210) had significantly higher body mass index (P=0.015) and waist circumference (P=0.028) and significantly higher levels of serum leptin (P=0.022) than those without the allele. Further studies will determine whether the Pro12Ala variant itself, or other genetic variation at PPAR-gamma, is responsible for this association with measures of obesity in Mexican Americans.
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