Journal
BIOMATERIALS
Volume 34, Issue 30, Pages 7444-7452Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2013.06.060
Keywords
Gastrointestinal tract; Upconversion nanoprobes; Low-toxic; Binary contrast agent; Multimodal imaging
Funding
- National Basic Research Program of China [2010CB720602, 2011CB936004]
- National Natural Science Foundation of China [91213302, 21210002, 21072182]
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Nanoparticulate contrast agents have attracted a great deal of attention along with the rapid development of modern medicine. Here, a binary contrast agent based on PAA modified BaYbF5:Tm nanoparticles for direct visualization of gastrointestinal (GI) tract has been designed and developed via a one-pot solvothermal route. By taking advantages of excellent colloidal stability, low cytotoxicity, and neglectable hemolysis of these well-designed nanoparticles, their feasibility as a multi-modal contrast agent for GI tract was intensively investigated. Significant enhancement of contrast efficacy relative to clinical barium meal and iodine-based contrast agent was evaluated via X-ray imaging and CT imaging in vivo. By doping Tm3+ ions into these nanoprobes, in vivo NIR-NIR imaging was then demonstrated. Unlike some invasive imaging modalities, non-invasive imaging strategy including X-ray imaging, CT imaging, and UCL imaging for GI tract could extremely reduce the painlessness to patients, effectively facilitate imaging procedure, as well as rationality economize diagnostic time. Critical to clinical applications, long-term toxicity of our contrast agent was additionally investigated in detail, indicating their overall safety. Based on our results, PAA-BaYbF5:Tm nanoparticles were the excellent multi-modal contrast agent to integrate X-ray imaging, CT imaging, and UCL imaging for direct visualization of GI tract with low systemic toxicity. (C) 2013 Elsevier Ltd. All rights reserved.
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