Journal
INFECTION AND IMMUNITY
Volume 68, Issue 4, Pages 1840-1848Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.68.4.1840-1848.2000
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- Wellcome Trust Funding Source: Medline
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In this study, we have analyzed hematopoietic activity in the spleen, bone marrow, and blood of BALB/c and scid mice infected with Leishmania donovani. Our analysis demonstrates that infection induces a rapid but transient mobilization of progenitor cells into the circulation, associated with elevated levels of granulocyte/ macrophage colony-stimulating factor (GM-CSF) and MIP-1 alpha. From 14 to 28 days postinfection, when parasite expansion begins in the spleen and bone marrow; both the frequency and cell cycle activity of hematopoietic progenitors, particulary CFU-granulocyte, monocyte, are dramatically increased in these organs. This is associated with increased accumulation of mRNA far GM-CSF, M-CSF, and G-CSF, but not interleukin-3. Our data also illustrate that hematopoietic activity, as assessed by changes in the frequency of progenitor cell populations and their levels of cell cycle activity, can be regulated in both a T-cell-independent and T-cell-dependent, as well as in an organ-specific, manner. Collectively, these data add to our knowledge of the long-term changes which occur in organs in which L. donovani is able to persist.
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