Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 12, Issue 2, Pages 250-256Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0955-0674(99)00083-6
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Interactions between cells and the extracellular matrix (ECM) result in the regulation of cell growth, cell differentiation and cell migration. These interactions are mediated by integrins and growth factor receptors and intracellular effecters that couple these receptors to downstream components are key to the transduction of ECM signals. This review summarizes recent advances in our understanding of signal transduction via integrins, focusing on the role of integrin-linked kinase in some of these pathways. Research into this interesting protein is uncovering novel aspects of coordinated signaling by the ECM and growth factors.
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