Journal
BRITISH JOURNAL OF CANCER
Volume 82, Issue 8, Pages 1381-1386Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1054/bjoc.1999.1077
Keywords
bone metastases; bisphosphonates; prevention; prophylaxis
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Several animal models, as well as a number of cell culture experiments, indicate a prophylactic effect of bisphosphonates in respect of subsequent bone metastasis. Moreover, in preliminary clinical trials involving patients with advanced breast cancer and local or remote metastases, biophosphonates produced a reduction in new skeletal metastases. This overview summarizes and discusses the results of the latest investigations. It opens with a section on the pathophysiology of bone metastasis, which is followed by a report on animal models and first studies of bisphosphonate treatment as a new approach in systemic adjuvant therapy. (C) 2000 Cancer Research Campaign.
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