Journal
JOURNAL OF VIROLOGY
Volume 74, Issue 7, Pages 3404-3409Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.74.7.3404-3409.2000
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Funding
- Wellcome Trust Funding Source: Medline
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We have generated mice lacking the gene for beta interferon and report that they are highly susceptible to vaccinia virus infection. Furthermore, in cultured embryo fibroblasts, viral induction of alpha interferon and of 2-5A synthetase genes is impaired. We also show that beta interferon does not prime its own expression.
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