Journal
BIOMATERIALS
Volume 34, Issue 25, Pages 6058-6067Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2013.04.052
Keywords
Anticancer drugs; Cancer nanotechnology; Controlled release; Drug delivery; Molecular biomaterials; Nanomedicine
Funding
- National Natural Science Foundation of China [31270019, 51203085, 30900291]
- China Postdoctoral Science Foundation [2012M520242]
- Natural Science Foundation of Guangdong Province [S2012040006820, S2012010010046]
- Shenzhen Municipal Program for Building State and Shenzhen Key Laboratories [CXB201005260070A, CXB201104220043A]
- Science, Technology & Innovation Commission of Shenzhen Municipality [JCYJ20120616213729920, KQC201105310021A, JCYJ2012061419193 6420, JC201005270308A]
- Program for New Century Excellent Talents in University [NCET-11-0275]
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We developed a system of nanoparticles (NPs) of cholic acid functionalized, star-shaped block copolymer consisting of PLGA and vitamin E TPGS for sustained and controlled delivery of docetaxel for treatment of cervical cancer, which demonstrated superior in vitro and in vivo performance in comparison with the drug-loaded PLGA NPs and the linear PLGA-b-TPGS copolymer NPs. The star-shaped block copolymer CA-PLGA-b-TPGS of three branch arms was synthesized through the core-first approach and characterized by H-1 NMR, GPC and TGA. The drug- or coumarin 6-loaded NPs were prepared by a modified nanoprecipitation technique and then characterized in terms of size and size distribution, surface morphology and surface charge, drug encapsulation efficiency, in vitro release profile and physical state of the encapsulated drug. The CA-PLGA-b-TPGS NPs were found to have the highest cellular uptake efficiency, the highest antitumor efficacy compared with PLGA-b-TPGS NPs and PLGA NPs. The results suggest that such a star-shaped copolymer CA-PLGA-b-TPGS could be used as a new molecular biomaterial for drug delivery of high efficiency. (C) 2013 Elsevier Ltd. All rights reserved.
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