Journal
BIOMATERIALS
Volume 33, Issue 27, Pages 6507-6519Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2012.05.049
Keywords
Platinum drug; Paclitaxel; Combination therapy; Drug delivery; Micelles
Funding
- National Natural Science Foundation of China [21004062, 51103148, 20674084]
- 100 Talents Program of the Chinese Academy of Sciences [KGCX2-YW-802]
- Ministry of Science and Technology of China (973 Project) [2009CB930102]
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A strategy of preparing composite micelles containing both cisplatin(IV) prodrug and paclitaxel was developed, i.e., synthesizing a cisplatin(IV) conjugate and a paclitaxel conjugate starting with the same biodegradable and amphiphilic block copolymer, and co-assembling the two conjugates. The composite micelles could release effective anticancer drug cisplatin(II) upon cellular reduction and PTX via acid hydrolysis once they came into the cancerous cells. Moreover, the composite micelles displayed synergistic effect in vitro and the combination therapy in micellar dosage-form led to reduced systematic toxicity and enhanced antitumor efficacy in vivo. (c) 2012 Elsevier Ltd. All rights reserved.
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