Journal
BIOMATERIALS
Volume 33, Issue 6, Pages 1722-1729Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2011.11.044
Keywords
Nanobioelectronic nose; Human olfactory receptor; Conducting polymer nanotube; Antagonism
Funding
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology (MEST) [2011-0000331, 2011K000682, 2011-0020984, R31-10013]
- WCU (World Class University) through the NRF
- NRF through Korean government (MEST) [2011-0017125]
- National Research Foundation of Korea [R31-2012-000-10013-0, 2010-0020821, 2011-0017125, 2010-50232, 2009-0080242] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Sensing smell is a highly complex biological process, and characterizing and mimicking the interaction between the olfactory receptor (OR) protein and its ligands is extremely challenging. Herein, we report a highly sensitive and selective human nose-like nanobioelectronic nose (nbe-nose), which responds to gaseous odorants sensitively and selectively, has a signal specificity pattern similar to that in the cellular signal transduction pathway, and maintains an antagonistic behavior similar to the human nose. The human olfaction mechanism was mimicked by using carboxylated polypyrrole nanotubes (CPNTs) functionalized with human OR protein. The nbe-nose was able to detect gaseous odorants at a concentration as low as 0.02 parts-per-trillion (ppt), which was comparable to a highly trained, human expert's nose. The nbe-nose can be used scientifically for smell mechanism studies. It can be also applied to various fields that rely on smell monitoring for industrial and public purposes. (C) 2011 Elsevier Ltd. All rights reserved.
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