Journal
PHYTOCHEMISTRY
Volume 53, Issue 7, Pages 805-810Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0031-9422(00)00007-8
Keywords
Tripterygium wilfordii; triterpenoids; immunosuppressive activity
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The extract (T-II) of Tripterygium wilfordii Hook f. afforded four triterpenoids: wilforic acid D (3 beta,24-epoxy-2 alpha-hydroxy-24R*- ethoxy-29-friedelanoic acid); (E) 3 beta,24-epoxy-2-oxo-3 alpha-hydroxy-29-friedelanoic acid; (F) 2 beta-hydroxy-3-oxo-friedelan-29-oic acid; 29-hydroxy-3-oxo-olean-12-en-28-oic acid and 17 known triterpenoids. Their structures were established on the basis of spectroscopic studies. In a bioactivity analysis, only the known dulcioic acid compound showed a significant inhibitory effect on cytokine production. (C) 2000 Elsevier Science Ltd. All rights reserved.
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