Journal
JOURNAL OF VIROLOGY
Volume 74, Issue 8, Pages 3929-3931Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.74.8.3929-3931.2000
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Funding
- NIAID NIH HHS [AI20017] Funding Source: Medline
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Drugs such as WIN51711 that inhibit picornavirus replication are thought to block poliovirus infectivity by binding to the capsid and preventing structural transitions required for uncoating. We examined the activity of WIN51711 at temperatures where capsid flexibility is thought to be decreased. Below 37 degrees C, WIN51711 inhibits the binding of wild-type poliovirus to cells but does not affect the binding of a poliovirus mutant which is believed to undergo structural transitions more readily. These results suggest that the poliovirus capsid must undergo structural changes to bind to its cellular receptor.
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