Journal
BIOMATERIALS
Volume 33, Issue 34, Pages 8745-8756Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2012.08.010
Keywords
Silver nanoparticle; Poly(DL-lactic-co-glycolic acid) (PLGA); Silver nanoparticle/poly(DL-lactic-co-glycolic acid)-coated stainless steel alloy (SNPSA); Implant-associated infections; Antimicrobial osteoinductive
Funding
- US DoD [07128099]
- China Scholarship Council (CSC)
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Implant-associated bacterial infections are one of the most serious complications in orthopedic surgery. Treatment of these infections often requires multiple operations, device removal, long-term systemic antibiotics, and extended rehabilitation, and is frequently ineffective, leading to worse clinical outcomes and increased financial costs. In this study, we evaluated silver nanoparticle/poly(DL-lactic-co-glycolic acid) (PLGA)-coated stainless steel alloy(SNPSA) as a potential antimicrobial implant material. We found that SNPSA exhibited strong antibacterial activity in vitro and ex vivo, and promoted MC3T3-E1 pre-osteoblasts proliferation and maturation in vitro. Furthermore, SNPSA implants induced osteogenesis while suppressing bacterial survival in contaminated rat femoral canals. Our results indicate that SNPSA has simultaneous antimicrobial and osteoinductive properties that make it a promising therapeutic material in orthopedic surgery. Published by Elsevier Ltd.
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