Journal
BIOMATERIALS
Volume 33, Issue 14, Pages 3733-3742Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2012.01.063
Keywords
Upconversion nanophosphors; NaLuF4; Large-animal imaging; Upconversion luminescence imaging
Funding
- National Natural Science Funds for Distinguished Young Scholars [20825101]
- State Key Basic Research Program of China [2011AA03A407, 2012CB932403]
- Shanghai Sci. Tech. Comm. [11XD1400200, 1052nm03400]
- innovative team of Ministry of Education of China [IRT0911]
- Shanghai Leading Academic Discipline Project [B108]
- CAS/SAFEA International Partnership Program for Creative Research Teams
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A new upconversion luminescence (UCL) nanophosphors based on host matrix of cubic NaLuF4 with bright luminescence have been synthesized by a solvothermal method, facilitate the nanocrystals potential candidates for imaging in vivo, especially large-animals. The sub-20 nm NaLuF4 co-doped Yb3+ and Er3+ (Tm3+) showed about 10-fold stronger UCL emission than that of corresponding hexagonal NaYF4-based nanocrystals with a 20 nm diameter. Near-infrared to near-infrared (NIR-to-NIR) UCL emission of PAA-coated NaLuF4:20%Yb,1%Tm (PAA-Lu-Tm) can penetrate > 1.5 cm tissue of pork with high contrast. Based on super-strong UCL emission and deep penetration. PAA-Lu-Tm as optical bioprobe has been demonstrated by in vivo UCL imaging of a normal black mouse, even rabbit with excellent signal-to-noise ratio. Furthermore, such cubic NaLuF4-based nanophosphor was applied in lymph node imaging of live Kunming mouse with rich white fur. (C) 2012 Elsevier Ltd. All rights reserved.
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