Journal
BIOMATERIALS
Volume 33, Issue 1, Pages 137-145Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2011.09.057
Keywords
Regenerative medicine; Regeneration; Tissue interfaces; Rapid prototyping; Biomimetics; Wound repair
Funding
- NIH/NIDCR [DE 13397]
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [R01DE013397] Funding Source: NIH RePORTER
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Regeneration of bone-ligament complexes destroyed due to disease or injury is a clinical challenge due to complex topologies and tissue integration required for functional restoration. Attempts to reconstruct soft-hard tissue interfaces have met with limited clinical success. In this investigation, we manufactured biomimetic fiber-guiding scaffolds using solid free-form fabrication methods that custom fit complex anatomical defects to guide functionally-oriented ligamentous fibers in vivo. Compared to traditional, amorphous or random-porous polymeric scaffolds, the use of perpendicularly oriented micro-channels provides better guidance for cellular processes anchoring ligaments between two distinct mineralized structures. These structures withstood biomechanical loading to restore large osseous defects. Cell transplantation using hybrid scaffolding constructs with guidance channels resulted in predictable oriented fiber architecture, greater control of tissue infiltration, and better organization of ligament interface than random scaffold architectures. These findings demonstrate that fiber-guiding scaffolds drive neogenesis of triphasic bone-ligament integration for a variety of clinical scenarios. (C) 2011 Elsevier Ltd. All rights reserved.
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