Journal
BRAIN RESEARCH REVIEWS
Volume 32, Issue 1, Pages 172-180Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-0173(99)00078-8
Keywords
development; cochlea; gap junction; connexin 26
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Gap junctions play a pivotal role in embryonic development by forming specialized regions of cell-cell communication. In this study, we demonstrate the temporal-spatial distribution of connexin 26 in the embryonic and early postnatal mouse cochlea. Our results show localization of this gap junction protein to specific cochlear structures, including the inner and outer sulcus cells, the supporting cells of the inner hair cells, the mesenchyme derived portion of the stria vascularis, and the cells of the spiral ligament that interface with the basal cells of the stria vascularis. This suggests that this gap junction protein of served patterns of connexin 26 distribution is important for the differentiation and development of these structures (e.g., the role of the inner sulcus cells in producing the tectorial membrane). (C) 2000 Elsevier Science B.V. All rights reserved.
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