Journal
BIOMATERIALS
Volume 33, Issue 17, Pages 4392-4402Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2012.02.056
Keywords
Mesoporous silica; Nanoparticle; Hierarchical nanostructures; Drug delivery; Luminescence imaging; Theranostic nanomedicine
Funding
- National Nature Science Foundation of China [51102259, 51132009, 50823007, 50972154]
- Science and Technology Commission of Shanghai [10430712800, 11nm0505000, 11nm0506500]
- Science Foundation for Youth Scholar of State Key Laboratory of High Performance Ceramics and Superfine Microstructures [SKL201001]
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A hierarchical theranostic nanostructure with carbon and Si nanocrystals respectively encapsulated in the mesopores and within the framework of mesoporous silica nanoparticles (CS-MSNs) was constructed by a bottom-up self-assembly strategy combining an in situ one-step carbonization/crystallization approach. CS-MSNs exhibited narrow size distribution, high payload of insoluble drugs and unique NIR-to-Vis luminescence imaging feature. The bio-conjugated CS-MSNs with a PEGylated phospholipid compound and hyaluronic acid showed excellent dispersivity and could specifically target cancer cells overexpressing CD44, deliver insoluble drugs into these cells and consequently kill them effectively, and also fluorescently image them simultaneously in a unique and attractive NIR-to-Vis luminescence imaging fashion, providing a promising opportunity for cancer theranostics. (C) 2012 Elsevier Ltd. All rights reserved.
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