Journal
BIOMATERIALS
Volume 33, Issue 21, Pages 5384-5393Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2012.04.002
Keywords
CT; NIR-fluorescence; Contrast medium; Small animal imaging
Funding
- National Natural Science Foundation of China Research [50823007, 50972154, 51132009, 51072212, 51102259, 21172043]
- Science and Technology Commission of Shanghai [11nm0505000, 10430712800]
- Fudan University [EYF163006]
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Early diagnosis that combines the high-resolutional CT and sensitive NIR-fluorescence bioimaging could provide more accurate information for cancerous tissues, which, however, remain a big challenge. Here we report a simple bimodal imaging platform based on PEGylated NaYbF4: Tm3+ nanopaticles (NPs) of less than 20 nm in diameter for both CT and NIR-fluorescence bioimaging. The as-designed nanoprobes showed excellent in vitro and in vivo performances in the dual-bioimaging, very low cytotoxicity and no detectable tissue damge in one month. Remarkably, the Yb3+ in the lattice of NaYbF4: Tm3+ NPs functions not only as a promising CT contrast medium due to its high X-ray absorption coefficiency, but also an excellent sensitizer contributing to the strong NIR-fluorescent emissions for its large NIR absorption cross-section. In addition, these NPs could be easily excreted mainly via feces without detectable remnant in the animal bodies. (C) 2012 Elsevier Ltd. All rights reserved.
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