Journal
BIOMATERIALS
Volume 33, Issue 21, Pages 5394-5405Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2012.04.025
Keywords
Upconversion luminescence; Upconversion nanoparticle; Multi-modality imaging; Rare-earth nanomaterials; Lanthanide nanoparticle
Funding
- National Natural Science Funds [20825101]
- National Science Foundation of China [91027004]
- Shanghai Sci. Tech. Comm. [11XD1400200, 1052 nm03400]
- Shanghai Leading Academic Discipline Project [B108]
- CAS/SAFEA
- Shanghai Key Laboratory of Functional Magnetic Resonance Imaging
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Multimodality molecular imaging has recently attracted much attention, because it can take advantage of individual imaging modalities by fusing together information from several molecular imaging techniques. Herein, we report a multifunctional lanthanide-based nanoparticle for near-infrared to near-infrared (NIR-to-NIR) upconversion luminescence (UCL), X-ray computed tomography (CT) and T-1-enhanced magnetic resonance (MR) trimodality in-vivo imaging. By careful selection of the lanthanide elements, core shell structured lanthanide-based nanoparticles, NaLuF4:Yb3+,Tm3+@SiO2-GdDTPA nanoparticles (UCNP@SiO2-GcIDTPA) have been designed and synthesized. We also prove that the application of UCNP@SiO2-GdDTPA for NIR-to-NIR UGL, CT and MRI multi-modality in-vivo imaging can be established successfully. In addition, the biological toxicity of UCNP@SiO2-GdDTPA is evaluated by the methyl thiazolyl tetrazolium (MIL) assay and histological analysis of viscera sections. 2012 Elsevier Ltd. All rights reserved.
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