Journal
KIDNEY INTERNATIONAL
Volume 57, Issue -, Pages S22-S26Publisher
ELSEVIER SCIENCE INC
DOI: 10.1046/j.1523-1755.2000.07512.x
Keywords
progressive renal disease; proteinuria; hypoxia; fibrosis; tubulointerstitium
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The question of why chronic renal diseases progress is a topic only recently investigated. Putative causes such as proteinuria do not account for all aspects of progressive renal disease. An alternative mechanism, chronic hypoxia, is proposed that might better explain certain elements of progressive renal disease, but elements of the hypothesis remain subject to further study.
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