Journal
BIOMATERIALS
Volume 33, Issue 29, Pages 7138-7150Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2012.06.068
Keywords
siRNA; Nanocarriers; Transfection; Polyplex; Cytotoxicity
Ask authors/readers for more resources
Increasing knowledge about molecular mechanisms of endogenous RNA interference (RNAi) and small interfering RNAs (siRNAs) has been incorporated into innovative nucleic acid medicines for treatment of diseases such as cancers. Although RNAi and siRNA have the potential to become powerful therapeutic drugs, their delivery to the target site represents a major challenge. The design and creation of nanocarriers for the safe and efficient delivery of siRNA towards their potential applications site is one of the challenging and rapidly growing areas of research since they have to overcome the commonly encountered biological barriers. In this review, we discuss the recent nanotechnological strategies for siRNA delivery by using different carriers such as liposomes, dendrimers and carbon nanotubes. (C) 2012 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available