Journal
VIRUS RESEARCH
Volume 67, Issue 2, Pages 173-178Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0168-1702(00)00141-6
Keywords
apoptosis; hepatitis C virus; TNF-alpha
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Funding
- NIAID NIH HHS [R01AI45144] Funding Source: Medline
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Hepatitis C virus (HCV) often causes a prolonged and persistent infection which may lead to hepatocellular carcinoma. We have previously reported that the nonstructural 5A (NS5A) protein of HCV promotes cell growth [Ghosh, A.K., Steele, R., Meyer, K., Ray, R., Ray, R.B., 1999. Hepatitis C virus NSSA protein modulates cell cycle regulatory genes and promotes cell growth. J. Gen. Virol. 80, 1179-1183]. In this study, we investigated the role of HCV NS5A (genotype la, strain H) in TNF-alpha induced apoptotic cell death. HepG2 cells expressing NS5A exhibited an inhibitory role in relation to TNF-alpha mediated apoptotic cell death. The NS5A protein blocked the activation of caspase-3 and inhibited proteolytic cleavage of the death substrate poly (ADP-ribose) polymerase in TNF-alpha induced cells. Together, these results suggest that HCV NSSA protein protects against TNF-alpha mediated apoptotic cell death. (C) 2000 Published by Elsevier Science B.V. All rights reserved.
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