Journal
BIOMATERIALS
Volume 33, Issue 21, Pages 5468-5477Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2012.04.005
Keywords
Controlled drug release; Hyaluronic acid(s); Hydrogel(s); Layer-by-layer assembly; Nanocarrier(s); Paclitaxel
Funding
- National Research Foundation of Korea (NRF)
- Korea Ministry of Education, Science, and Technology (MEST) [2010-0018290]
- Korea Ministry of Education, Science, and Technology (MEST) in SNU Chemical Engineering
- Korea Ministry of Education, Science, and Technology (MEST) WCU [R31-10013]
- Ministry of Health and Welfare of Korea [A101539]
- Korea Health Promotion Institute [A101539] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2010-0018290] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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We developed hyaluronic acid (HA)-based multilayer films capturing polymeric nanocarriers (NCs) for drug delivery. The electrostatic interactions between positively charged linear polyethylene imines (LPEI) and negatively charged HAs are the main driving forces to form multilayers based on the layer-by-layer (LbL) deposition. NCs were easily incorporated within the multilayer film due to intra- and/or inter-hydrogen bonding among HA chains. The amount of NCs captured by the HA chains was varied by the ratio between HAs and NCs as well as the length (i.e., molecular weight) and absolute number density of HAs in solution. Biocompatibility of the NC-capturing HA multilayer films was tested with the human dermal fibroblast (HDF) culture. In addition, the controlled release of paclitaxel (M) from the HA multilayer films successfully led to the apoptosis of human aortic smooth muscle cells (hSMC) in vitro, implying that the NC-capturing HA multilayer films would be quite useful as drug-eluting stent systems to prevent the restenosis after surgery. (C) 2012 Elsevier Ltd. All rights reserved.
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