Journal
BIOMATERIALS
Volume 33, Issue 30, Pages 7547-7555Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2012.06.076
Keywords
Ag nanoparticles; Hydroxyl radicals; Oxygen; Nanosafety; ESR; Hydrogen peroxide
Funding
- FY11 FDA Nanotechnology CORES Program
- Maryland NanoCenter
- Maryland NanoCenter, NispLab
- NSF as a MRSEC Shared Experimental Facility
Ask authors/readers for more resources
Many of the chemical and biological effects of silver nanoparticles (Ag NPs) are attributed to the generation of reactive oxygen species (ROS). ESR spectroscopy was used to provide direct evidence for generating ROS during decomposition of H2O2 assisted by Ag NPs. Hydroxyl radical formation was observed under acidic conditions and was accompanied by dissolution of Ag NPs. In contrast, evolution of O-2 was observed in alkaline solutions containing H2O2 and Ag NPs: however, no net dissolution of Ag NPs was observed due to re-reduction of Ag+ as evidenced by a cyclic reaction. Since H2O2 is a biologically relevant product being continuously generated in cells, these results obtained under conditions mimicking different biological microenvironments may provide insights for finding new biomedical applications for Ag NPs and for risk assessment. (C) 2012 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available