Journal
BIOMATERIALS
Volume 33, Issue 18, Pages 4443-4450Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2012.03.024
Keywords
Nanoparticle; Self-assembly; Peptide; Surface modification
Funding
- University Grant Council of Hong Kong Special Administrative Region, China [HKBU 201208]
- Hong Kong Baptist University [FRG2/08-09/073, FRG2/09-10/037]
- University Grant Committee of the Hong Kong Special Administrative Region, China [SEG_HKBU06]
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The influence of nanoparticles of various sizes and surface functionalities on the self-assembling fibrillogenesis of beta-amyloid (1-40) peptide was investigated. Functionalized nanoparticles including quantum dots and gold nanoparticles were co-incubated with monomeric A beta(1-40) peptides under seed-mediated growth method to study their influences on the elongation phase of the fibrillogenesis. It is observed that charge-to-surface area ratio of the nanoparticles and the functional moiety and electrostatic charges of the conjugated ligands on the particle surfaces took crucial regulatory role in the A beta(1-40) fibrillogenesis. (C) 2012 Elsevier Ltd. All rights reserved.
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