Journal
BIOMATERIALS
Volume 33, Issue 22, Pages 5524-5533Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2012.04.017
Keywords
Age/ageing; ECM (extracellular matrix); Scaffold; Macrophage; Immune response; Mechanical properties
Funding
- NIAMS NIH HHS [R01 AR054940] Funding Source: Medline
- NIA NIH HHS [F31 AG042199] Funding Source: Medline
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Biologic scaffolds composed of mammalian extracellular matrix (ECM) are routinely used for the repair and reconstruction of injured or missing tissues in a variety of pre-clinical and clinical applications. However, the structural and functional outcomes have varied considerably. An important variable of xenogeneic biologic scaffolds is the age of the animal from which the ECM is derived. The present study compared the in vivo host response and remodeling outcomes of biologic scaffolds composed of small intestinal submucosa (SIS)-ECM harvested from pigs that differed only in age. Results showed that there are distinct differences in the remodeling characteristics as a consequence of source animal age. Scaffolds derived from younger animals were associated with a more constructive, site appropriate, tissue remodeling response than scaffolds derived from older animals. Furthermore, the constructive remodeling response was associated with a dominant M2 macrophage response. (C) 2012 Elsevier Ltd. All rights reserved.
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