Journal
BIOMATERIALS
Volume 32, Issue 29, Pages 7253-7262Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2011.06.015
Keywords
Gene delivery; Nanovector; PEI; Target; Cell-penetrating peptide
Funding
- National High Technology Development Program of China (863 Program) [2007AA03Z355]
- Zhejiang Provincial Natural Science Foundation of China [Z207572]
- National Natural Science Foundation of China [21074007]
- Research Fund for the Doctoral Program of Higher Education of China [20090010120007]
- Program for New Century Excellent Talents in University [NCET-10-0203]
- SRF for ROCS, SEM (BUCT)
Ask authors/readers for more resources
Target ligand folic acid (FA) and cell-penetrating peptide octaarginine (R8) were coupled with the gene vectors (PEI600-CyD, PC) composed of beta-cyclodextrin (beta-CyD) and low-molecular-weight polyethylenimine (PEI, Mw 600) to form nanovectors for highly efficient gene delivery to tumor cells. The resultant ternary nanocomplexes of FA-PC/R8-PC/pDNA produced excellent gene transfaction abilities in the folate receptor (FR)-positive tumor cells in vitro and in vivo. The FR-mediated endocytosis and the R8-mediated transmembrane functionality together contributed to the high transfection levels. This study provides a promising means to produce gene nanovectors for in vivo applications. (C) 2011 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
