Journal
BIOMATERIALS
Volume 32, Issue 36, Pages 9796-9809Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2011.08.086
Keywords
Folic acid; Silica; Gold nanorods; Photo-thermal therapy; Radiation therapy; X-ray imaging
Funding
- National Key Basic Research Program (973 Project) [2010CB933901, 2011CB933100]
- Important National Science & Technology Specific Projects [2009ZX10004-311]
- National Natural Scientific Fund [20803040]
- Special Project for Nanotechnology from Shanghai [1052nm04100]
- Ministry of Education of China [NCET-08-0350]
- Shanghai Science and Technology Fund [10XD1406100]
- Shanghai Jiao Tong University
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Multifunctional nanoprobes are designed to own various functions such as tumor targeting, imaging and selective therapy, which offer great promise for the future of cancer prevention, diagnosis, imaging and treatment. Herein, silica was applied to replace cetyltrimethylammonium bromide (CTAB) molecules on the surface of gold nanorods (GNRs) by the classic Stober method, thus eliminating their cytotoxicity and improving their biocompatibility. Folic acid molecule was covalently anchored on the surface of GNRs with silane coupling agent. The resultant folic acid-conjugated silica-modified GNRs show highly selective targeting, enhanced radiation therapy (RT) and photo-thermal therapy (PTT) effects on MGC803 gastric cancer cells, and also exhibited strong X-ray attenuation for in vivo X-ray and computed tomography (CT) imaging. In conclusion, the as-prepared nanoprobe is a good candidate with excellent imaging and targeting ability for X-ray/CT imaging-guided targeting dual-mode enhanced RT and PTT. (C) 2011 Elsevier Ltd. All rights reserved.
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