Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 12, Issue 2, Pages 229-234Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0955-0674(99)00080-0
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Protein 4.1 (also called band 4.1 or simply 4.1) was originally identified as an abundant protein of the human erythrocyte, in which it stabilizes the spectrin/actin cytoskeleton. The protein and its relatives have since been found in many cell types of metazoan organisms and they are often concentrated in the nucleus, as well as in cell-cell junctions. They form multimolecular complexes with transmembrane and membrane-associated proteins, and these complexes may be important for both structural stability and signal transduction at sites of cell contact.
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