Journal
BIOMATERIALS
Volume 32, Issue 16, Pages 3899-3909Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2011.02.013
Keywords
Antimicrobial coatings; Implant-associated infection; Biofilm resistance; Blood/tissue toxicity; Antimicrobial peptides; Polymer brushes
Funding
- Natural Science and Engineering Council of Canada (NSERC)
- Canadian Institutes of Health Research (CIHR)
- Advanced Foods and Materials Network
- Canadian Blood Services (CBS)
- Canadian Cystic Fibrosis Foundation
- Canadian Foundation for Innovation (CFI)
- Michael Smith Foundation for Health Research (MSFHR)
- MSFHR
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Bacterial colonization on implant surfaces and subsequent infections are one of the most common reasons for the failure of many indwelling devices. Several approaches including antimicrobial and antibioticeluting coatings on implants have been attempted; however, none of these approaches succeed in vivo. Here we report a polymer brush based implant coating that is non-toxic, antimicrobial and biofilm resistant. These coating consists of covalently grafted hydrophilic polymer chains conjugated with an optimized series of antimicrobial peptides (AMPs). These tethered AMPs maintained excellent broad spectrum antimicrobial activity in vitro and in vivo. We found that this specially structured robust coating was extremely effective in resisting biofilm formation, and that the biofilm resistance depended on the nature of conjugated peptides. The coating had no toxicity to osteoblast-like cells and showed insignificant platelet activation and adhesion, and complement activation in human blood. Since such coatings can be applied to most currently used implant surfaces, our approach has significant potential for the development of infection-resistant implants. (C) 2011 Elsevier Ltd. All rights reserved.
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