Journal
BIOMATERIALS
Volume 32, Issue 11, Pages 2871-2877Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2011.01.019
Keywords
Neurite outgrowth; Iron oxide nanoparticle; Neuronal differentiation; Extracellular matrix; Cell adhesion
Funding
- Ministry of Education, Science, and Technology (MEST) [2010-0002229, 2010K001137, 2010-0000825]
- Seoul Science Fellowship
- National Research Foundation of Korea [2009-0080242, 2010-0029138, 2010-50232, 2002-0046427, 2009-0082946] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Despite the many potential therapeutic applications of iron oxide nanoparticle such as its use as an imaging and targeting tool, its biological effects have not yet been extensively characterized. Herein, we report that iron oxide nanoparticles taken up by PC12 cells can enhance neurite outgrowth. PC12 cells exposed to both iron oxide nanoparticles and nerve growth factor (NGF) synergistically increased the efficiency of neurite outgrowth in a dose-dependent manner. This may have resulted from the activation of cell adhesion molecules that are associated with cell matrix interactions through iron. Immunoblotting assays also revealed that both neural specific marker protein and cell adhesion protein expression were upregulated by iron oxide nanoparticles compared with non-treated cells via activation of the mitogen-activated protein kinase (MAPK) signaling pathway. Our findings point to the possibility that iron oxide nanoparticles can affect cell substrate interactions and regulate cell behaviors, which provides clinical insights into potential neurologic and therapeutic applications of iron oxide nanoparticles. (C) 2011 Elsevier Ltd. All rights reserved.
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