Journal
PLANTA MEDICA
Volume 66, Issue 3, Pages 228-230Publisher
GEORG THIEME VERLAG
DOI: 10.1055/s-2000-8561
Keywords
Xanthium strumarium; Compositae; caffeic acid; antihyperglycemic effect; insulin-independent action; glucose challenge test; glucose uptake
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The antihyperglycemic effect of caffeic acid, one of the phenolic compounds contained in the fruit of Xanthium strumarium, was investigated. After an intravenous injection of caffeic acid into diabetic rats of both streptozotocin-induced and insulin-resistant models, a dose-dependent decrease of plasma glucose was observed. However, a similar effect was not produced in normal rats. An insulin-independent action of caffeic acid can thus be considered. Otherwise, this compound reduced the elevation of plasma glucose level in insulin-resistant rats receiving a glucose challenge test. Also, glucose uptake into the isolated adipocytes was raised by caffeic acid in a concentration-dependent manner. Increase of glucose utilization by caffeic acid seems to be responsible for the lowering of plasma glucose.
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