Journal
BIOMATERIALS
Volume 32, Issue 18, Pages 4205-4210Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2011.02.029
Keywords
RGD; Integrin; Extracellular matrix; Tissue regeneration; Cell adhesion
Funding
- NIAMS NIH HHS [R01 AR051539, R01 AR051539-04] Funding Source: Medline
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Despite many years of in vitro research confirming the effectiveness of RGD in promoting cell attachment to a wide variety of biomaterials, animal studies evaluating tissue responses to implanted RGD-functionalized substrates have yielded more variable results. The goals of this report are to present some of the reasons why cell culture studies may not always reliably predict in vivo responses, and more importantly, to highlight potential applications that may benefit from the use of RGD peptides. (C) 2011 Elsevier Ltd. All rights reserved.
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