Journal
BIOMATERIALS
Volume 32, Issue 4, Pages 1139-1147Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2010.09.040
Keywords
Platinum; Nanostructures; Oxidase; Peroxidase; Catalase; Immunoassays
Funding
- National Natural Science Foundation of China [20773032]
- National Basic Research Program of China [2006CB932602, 2006CB705600]
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In this paper, we demonstrated that Au nanorods coated with a shell composed of Pt nanodots (Au@Pt nanostructures) exhibited intrinsic oxidase-like, peroxidase-like and catalase-like activity, catalyzing oxygen and hydrogen peroxide reduction and the dismutation decomposition of hydrogen peroxide to produce oxygen. Based on these findings, we established an Au@Pt nanostructures based enzyme linked immunosorbent assay (ELISA) for the detection of mouse interleukin 2 (IL-2). In comparison with natural enzymes, Au@Pt nanostructures have advantages of low cost, easy preparation, better stability, and tunable catalytic activity (compared with HRP), which make them a promising enzyme mimetic candidate and may find potential applications in biocatalysis, bioassays, and nano-biomedicine such as reactive oxygen species (ROS)-related fields (anti-aging and therapeutics for neurodegenerative diseases and cancers). (c) 2010 Elsevier Ltd. All rights reserved.
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