Journal
BIOMATERIALS
Volume 32, Issue 30, Pages 7687-7694Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2011.06.060
Keywords
Hyaluronic acid; Cucurbituril; Multi-functionality; Host-guest chemistry; Theranostic system
Funding
- Korean Ministry of Education, Science and Technology [R31-2008-000-10059-0]
- Korea Research Council of Fundamental Science Technology
- POSCO
- National Research Foundation of Korea (NRF)
- Ministry of Education. Science and Technology [2009-0081871, 2009-0084578]
- NRF
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Theranostic systems have been explored extensively for a diagnostic therapy in the forms of polymer conjugates, implantable devices, and inorganic nanoparticles. In this work, we report theranostic systems in situ assembled by host-guest chemistry responding to a request. As a model theranostic system on demand, cucurbit[6]uril-conjugated hyaluronate (CB[6]-HA) was synthesized and decorated with FITC-spermidine (spmd) and/or formyl peptide receptor like 1 (FPRL1) specific peptide-spmd by simple mixing in aqueous solution. The resulting (FITC-spmd and/or peptide-spmd)@CB[6]-HA was successfully applied to the bioimaging of its target-specific delivery to B16F1 cells with HA receptors and its therapeutic signal transduction with elevated Ca(2+) and phosphor-extracellular signal-regulated kinase (pERK) levels in FPRL1-expressing human breast adenocarcinoma (FPRL1/MCF-7) cells. Finally, we could confirm in vitro and in vivo stability of the highly specific host-guest interaction. The on-demand theranostic platform technology using host-guest chemistry can be exploited for various bioimaging, biosensing, drug delivery, and tissue engineering applications. (C) 2011 Elsevier Ltd. All rights reserved.
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