Journal
BIOMATERIALS
Volume 32, Issue 21, Pages 4867-4876Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2011.03.024
Keywords
Carbon nanotubes; Magnetic nanoparticles; Magnetic resonance imaging; Hemolysis; Biodistribution; Elimination
Funding
- National Natural Science Foundation of China [50972092, 20971086, 50802059]
- Science and Technology Commission of Shanghai Municipality [065212050, S30406]
- Special Foundation of China Postdoctoral Science Foundation [201003282]
- Shanghai Key Laboratory of the Rare Earth Functional Materials [07dz22303]
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Fe3O4 nanoparticles were in situ loaded on the surface of multiwalled carbon nanotubes (MWCNTs) by a solvothermal method using diethylene glycol and diethanolamine as solvents and complexing agents. The as-prepared MWCNT/Fe3O4 hybrids exhibited excellent hydrophilicity, superparamagnetic property at room temperature, and a high T-2 relaxivity of 175.5 mM(-1) s(-1) in aqueous solutions. In vitro experiments revealed that MWCNT/Fe3O4 had an excellent magnetic resonance imaging (MRI) enhancement effect on cancer cells, and importantly, they displayed low cytotoxicity and neglectable hemolytic activity. After intravenous administration, the T-2-weighted MRI signal in the liver and spleen of mice decreased significantly, suggesting the potential application of the hybrids as MRI contrast agents. The organ biodistribution studies, histological analyses and elimination investigations showed that the hybrids were uptaken by the liver, lung and spleen after intravenous injection, and could be excreted from the liver and kidney. (C) 2011 Elsevier Ltd. All rights reserved.
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