Journal
BIOMATERIALS
Volume 32, Issue 29, Pages 7200-7208Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2011.05.094
Keywords
Core-shell nanocrystals; Upconversion luminescence; Magnetic resonance imaging; Multimodality imaging
Funding
- National Natural Science Funds for Distinguish Young Scholar [20825101]
- NHTPC [2011AA03A407]
- National Science Foundation of China [91027004]
- Shanghai Sci. Tech. Comm. [1052 nm03400]
- Shanghai Leading Academic Discipline Project [B108]
- CAS/SAFEA
- Key Laboratory of Functional Magnetic Resonance Imaging
- [IRT0911]
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New core-shell structured NaYF4:Yb3+,Tm3+@FexOy nanocrystals, with 20 nm Yb3+,Tm3+-co-doped NaYF4 nanocrystals as a core and 5 nm FexOy nanocrystals as a shell, have been synthesized and characterized by TEM and XRD analysis. These core shell nanocrystals exhibit excellent near-infrared upconversion luminescence (UCL) emission at 800 nm under excitation by a continuous-wave 980 nm laser and superparamagnetic properties with a saturation magnetization (Ms) of similar to 12 emu/g. Water-soluble nanocrystals were obtained by surface ligand exchange of oleic acid-coated precursor nanocrystals, and their internalization within living cells has been investigated by laser scanning UCL microscopy. Furthermore, the obtained core shell nanocrystals have been applied in dual-modality T-2-enhanced magnetic resonance (MR) and UCL imaging in vivo of the lymphatic system. Moreover, the toxicity of NaYF4:Yb3+,Tm3+@FexOy nanocrystals has also been evaluated by MTT assay, IC50 values, and histological analysis of lymphatic node sections. (C) 2011 Elsevier Ltd. All rights reserved.
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