Journal
BIOMATERIALS
Volume 32, Issue 30, Pages 7592-7599Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2011.06.029
Keywords
Quantum dots; Breast carcinoma; Molecular classification; Hormone receptor; HER2; Quantitative analysis
Funding
- Ministry of Education of China [4103005]
- National Natural Science Foundation of China [20921062]
- National Science Foundation for Distinguished Young Scholars of China [81000974]
- National Key Scientific Program (973)-Nanoscience and Nanotechnology [2011CB933600]
- Ministry of Public Health [2009ZX10004-107, 2008ZX10004-004]
- Health Department of Hubei Province [JX5B69]
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The emerging molecular breast cancer (BC) classification based on key molecules, including hormone receptors (HRs), and human epidermal growth factor receptor 2 (HER2) has been playing an important part of clinical practice guideline. The current molecular classification mainly based on their fingerprints, however, could not provide enough essential information for treatment decision making. The molecular information on both patterns and quantities could be more helpful to heterogeneities understanding for BC personalized medicine. Here we conduct quantitative determination of HRs and HER2 by quantum dots (QDs)-based quantitative spectral analysis, which had excellent consistence with traditional method. Moreover, we establish a new molecular classification system of BC by integrating the quantitative information of HER2 and HRs, which could better reveal BC heterogeneity and identify 5 molecular subtypes with different 5-year prognosis. Furthermore, the emerging 5 molecular subtypes based on simple quantitative molecules information could be as informative as multi-genes analysis in routine practice, and might help formulate a more personalized comprehensive therapy strategy and prognosis prediction. (C) 2011 Elsevier Ltd. All rights reserved.
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