Journal
BIOMATERIALS
Volume 31, Issue 34, Pages 9086-9091Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2010.08.046
Keywords
Drug delivery; Percutaneous protein absorption; Gold nanoparticle; Co-delivery; Transcutaneous immunization
Funding
- NIH [CA114612, NS066945]
- WCU project of South Korea [R31-2008-000-10103-01]
- Chinese Academy of Sciences
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An interesting nanoscale interfacial phenomenon mediated by gold nanoparticles (Au-NPs) was found, in that co-administration with Au-NPs enables percutaneous delivery of protein drugs. The Au-NPs with a mean size of 5 nm were revealed to be skin permeable, presumably due to the nano-bio interaction with skin lipids and the consequent induction of transient and reversible openings on the stratum corneum. Importantly, when simultaneously applied with Au-NPs, the protein drugs were also granted the ability to penetrate the skin barrier and migrate into the deep layers. This indicated that co-administration with the skin-permeable Au-NPs could mediate proteins across the skin barrier. Such co-delivery effect highlights a simple yet effective method for overcoming the skin barrier for percutaneous protein drug delivery. Employing this method, a non-invasive vaccine delivery strategy was developed, and by topically co-administrating antigens with Au-NPs, robust immune responses were elicited in the tested animals. The results provide the promise for achieving a needleless and self-administrable transcutaneous vaccination. (C) 2010 Elsevier Ltd. All rights reserved.
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