Journal
BIOMATERIALS
Volume 31, Issue 8, Pages 2072-2083Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2009.11.091
Keywords
316L stainless steel; Plasma polymerization; Stability; Stent; Heparin; Hemocompatibility
Funding
- National Natural Science Foundation of China [50673081]
- Ministry of Scientific and Technical Project of China [2005CB623904]
- Ministry of Education of China [NCET-07-0715]
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For an improved hemocompatibility of 316L stainless steel (SS), we develop a facile and effective approach to fabricating a pulsed-plasma polymeric allylamine (P-PPAm) film that possesses a high cross-linking degree and a high density of amine groups, which is used for subsequent bonding of heparin. The P-PPAm film as a stent coating shows good resistance to the deformation behavior of compression and expansion of a stent. Using deionized water as an aging medium, it is demonstrated that the heparin-immobilized P-PPAm (Hep-P-PPAm) surface has a good retention of heparin. The systematic in vitro hemocompatibility evaluation reveals lower platelet adhesion, platelet activation and fibrinogen activation on the Hep-P-PPAm surface, and the activated partial thromboplastin time prolongs for about 15 s compared with 316L SS. The P-PPAm surface significantly promotes adhesion and proliferation of endothelial cells (ECs). For the Hep-P-PPAm, although EC adhesion and proliferation is slightly suppressed initially, after cultivation for 3 days, the growth behavior of ECs is remarkably improved over 316L SS. In vivo results indicate that the Hep-P-PPAm surface successfully restrain thrombus formation by growing a homogeneous and intact shuttle-like endothelium on its surface. The Hep-P-PPAm modified 316L SS shows a promising application for vascular devices. (C) 2009 Elsevier Ltd. All rights reserved.
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