Journal
BIOMATERIALS
Volume 31, Issue 9, Pages 2517-2525Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2009.12.013
Keywords
Mesoporous inorganic-organic hybrid resins; Ionic characteristics; Hydrophilicity; Physical properties; Biocompatibility
Funding
- National Research Foundation (NRF) of Korea [R16-2008-138-01001-0(2008)]
- Ministry of Education, Science & Technology (MEST)
- National Research Foundation of Korea [R16-2008-138-01001-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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New mesoporous silicate-titania resin systems hybridized with 4.5-dihydroxy-m-benzenedisulfonic acid and poly(ethylene glycol)-dimethacrylate component were developed These inorganic-organic hybrid resins were found to reveal highly controlled ionic and hydrophilic surface with excellent durability and adhesion onto various substrates The resin films revealed high resistance to nonspecific adsorption of fibrinogen and to adherence by several bacterial pathogens such as Escherichia coli, Staphylococcus aureus. Staphylococcus epidermidis and Enterococcus faecalis Furthermore, excellent biocompatibility of the developed resins was proved by both HEp-2 cell adhesion in vitro and subcutaneous Implantation in mice The inorganic-organic hybrid resins are strongly promising for biomedical applications Including biomedical devices and biosensors (C) 2009 Elsevier Ltd All rights reserved
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