Journal
BIOMATERIALS
Volume 31, Issue 33, Pages 8716-8723Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2010.07.095
Keywords
Nanoparticle; MRI (magnetic resonance imaging); Surface modification; Poly(D,L-lactide-co-glycolide); Gadolinium; Chelate
Funding
- European Commission [NMP4-CT-2006-026668]
- DiMI [LSHB-CT-2005-512146]
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The preparation of particulate contrast agents for magnetic resonance imaging (MRI) based on biodegradable poly(D,L-lactide-co-glycolide) (PLGA) nanocarriers is reported. By spacer-aided covalent surface-grafting of the prominent chelating ligands diethylenetriaminepentaacetic acid (DTPA) and 1,4,7, 10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), respectively, up to 236 mu g gadolinium per mg PLGA can be immobilized in a stable manner. Due to the localisation at the particle surface, water protons may effectively interact with the gadolinium chelates and the modified particles exhibit high proton relaxivities as confirmed by T1 relaxivities of up to 17.5 mM(-1)s(-1) (25 degrees C, 1.41 T) in case of Gd-DOTA-functionalized carriers and also supported by NMRD profiles. The obtained values compare favorably with marketed low-molecular weight contrast agents and thus suggest suitability for in vivo use. (C) 2010 Elsevier Ltd. All rights reserved.
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