Journal
BIOMATERIALS
Volume 31, Issue 10, Pages 2866-2873Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2009.12.025
Keywords
Cell viability; Copper; Cytotoxicity; In vitro test; MRI (magnetic resonance imaging); Surface modification
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We have developed an ion-sensing nanoparticle that is comprised of a superparamagnetic iron oxide (SPIO) core encapsulated with a porous silica shell. The latter can be readily anchored with ligands capable of coordinating with positron-emitting metal. Evidently, this nanoparticle has a great potential for use in cell tracking with magnetic resonance (MR) imaging and positron emission tomography (PET). Herein we report the synthesis, surface functionalization and characterization of the magnetic nanoparticle-based probes and evaluate their cell-labeling efficacy, cytoxicity and relaxivity in comparison to one of the most commonly utilized MRI contrast agents, Feridex (R). Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.
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