Journal
BIOMATERIALS
Volume 31, Issue 18, Pages 4958-4963Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2010.02.053
Keywords
Leukemia; Drug resistance; Cadmium telluride; Daunorubicin; Bio-imaging; Drug delivery
Funding
- National NSFC [90713023, 20675014, 20535010]
- National Basic Research Program of China [2010CB732404]
- National High Technology Research and Development Program of China [2007AA022007]
- Ministry of Education of China (RFDP) [20090092110028]
- Natural Science Foundation of Jiangsu Province [BK2008149]
- Graduate Research and Innovation Program of Jiangsu Province [CX07B_177z]
- United States NSF-CREST [HRD0932421]
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Photoluminescent semiconductor quantum dots (QDs) have received significant attention in biological and biomedical fields because of their attractive properties. In this contribution, we have explored and evaluated the utilization of water-soluble nanocrystal CdTe quantum dots (QDs) capped with negatively charged 3-mercapitalpropionic acid (MPA)-QDs to enhance the drug uptake into the target cancer cells and the efficiency of the biomarker and cancer treatments, by using the cytotoxicity evaluation, total internal reflection fluorescence microscopy, electrochemistry and UV-Vis absorption spectroscopy. Our results illustrate that the MPA-CdTe QDs could effectively facilitate the interaction of anticancer agent daunorubicin (DNR) with leukemia cells and the efficiency of biolabeling in cancer cells. Therefore, the present study affords a new potential method for simultaneous cellular inhibition and imaging of cancer cells. (C) 2010 Elsevier Ltd. All rights reserved.
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