Journal
BIOMATERIALS
Volume 31, Issue 26, Pages 6823-6832Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2010.05.030
Keywords
Quantum dots; Dual-emissive particles; Multispectral fluorescence imaging; Sentinel lymph node; Prostate cancer
Funding
- Technology Foundation
- Ministry of Economic Affairs [STW BGT 7528]
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Fluorescence molecular imaging is rapidly increasing its popularity in image guided surgery applications. To help develop its full surgical potential it remains a challenge to generate dual-emissive imaging agents that allow for combined visible assessment and sensitive camera based imaging. To this end, we now describe multispectral InP/ZnS quantum dots (QDs) that exhibit a bright visible green/yellow exciton emission combined with a long-lived far red defect emission. The intensity of the latter emission was enhanced by X-ray irradiation and allows for: 1) inverted QD density dependent defect emission intensity, showing improved efficacies at lower QD densities, and 2) detection without direct illumination and interference from autofluorescence. (C) 2010 Elsevier Ltd. All rights reserved.
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